ORIGINAL CODE: 0009012, Free format text: 0000004197 00000 n The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. All information collection is solely used to support ChemPoint customers service communications. Your document download will begin shortly. Hydroquinone compositions are effective but have some undesirable side effects. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in This saturated dicarboxylic acid exists as a white powder. Do not put this product in the microwave. Found. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. A method of stabilizing a hydroquinone composition, comprising hydroquinone and one or more protected retinoids, comprising: maintaining pH of the composition at about 5.5 to about 8.0. stearic, palmitic, arachidic acids, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. The drug is freely soluble in water and in alcohol. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. Glycerol derivatives solubilise natural, hydrophilic antioxidants in biofuels. Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. The Molecular Weight is 110.11 g/mol. Van Haelst, P. Heesen, F. Van Der Wielen, H. Govers, Chemosphere 29, 16511660 (1994), Article Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. There are various other uses associated with its reducing power. %PDF-1.4 % Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. The experimental solubilities were correlated using two regression equations. Protected retinoid, with its skin benefit capabilities, may also be included with the hydroquinone composition. Can be destroyed by oxidizing it with an oxidizing mixture. [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. A common route involves hydroxylation of phenol. INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Why we like it: This affordable cream contains 2 percent hydroquinone, sunscreen, and costs around five dollars. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. vz >I d50dwp?i4,H3. M1 and M2 microemulsions contain ethanol as co-surfactant. Calorim. 0000004433 00000 n Res. However, hydroquinone discolors at the pH range of 7.0 to 8.5. 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. By acting as a free radical scavenger, hydroquinone serves to prolong the shelflife of light-sensitive resins such as preceramic polymers.[18]. It can also be found on eBay and Amazon. [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. Find answers in our support articles. Stir until uniform. Other adverse effects The solubility in water is 6.72g/L. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. Inhalation Remove to fresh air. volume42, Articlenumber:1 (2021) Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . 0000005089 00000 n 0000003660 00000 n Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. International Journal of Thermophysics [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. isosorbide, Ascorbic acid, i.e. Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. 20grams ofhydroquinonein 20oz is liquid is 10%. If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. application/pdf 12.4. This website uses cookies. The Density of hydroquinone is . In hydroquinone and sodium metabisulfite compositions, it is believed that the sodium metabisulfite oxidizes first and delays the start of any oxidation of the hydroquinone, so that excessive discoloration is delayed or totally avoided. This composition is color stabilized and cosmetically elegant. and solubility in water. At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. Natural antioxidants could replace hydroquinone derivatives used in industry. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. Phase A is added to the tank, which is held at a temperature of from about 70 to about 75 C, and in which a CO. Lastly, I'd like to add benzoic acid for preservation purposes. How to dissolve Hydroquinone to make 4 oz. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. Using a laser-monitoring observation technique, the solubility of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid were measured at temperatures ranging from 276.65 K to 345.10 K under the atmospheric pressure. Chem. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream Conversion factors (at 25 oc and normal atmospheric pressure) 1 ppm = 4.5 mg!m 3 GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection.Call a POISON CENTER or doctor/physician if you feel unwell.IF ON SKIN: Gently wash with plenty of soap and water.IF IN EYES: Rinse cautiously with water for several minutes. We have found that a cream containing 5% of hydroquinone and 0.05 % of laevo-ascorbic acid remains white, and the emulsion remains unbroken after many months of storage, The laevo-ascorbic or cevitamic acid is pr'eferably employed in the free condition; but if desired, the salts, and especially the water-soluble salts thereof, may be employed . V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= Gerhard Franz, Roger A. Sheldon "Oxidation" in. This chamber is lined with cells that secrete catalases and peroxidases. Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. It has a white-solid appearance. &"oq YcbX.=a*t R@ I'd like the consistency to be thin like a gel so that it absorbs quicker. 0000000731 00000 n This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. 1401417, Country of ref document: Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. Classical photo shops . The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . . Gravimetric method is used to measured hydroquinone solubility in water, ethanol and in water+ethanol binary mixtures at temperatures (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, 310.15 and 313.15)K. Mole fractions solubility of hydroquinone are correlated with temperature by using the Apelblat equation. Re: How to dissolve Hydroquinone to make 4 oz. 0000053439 00000 n The Campaign for Safe Cosmetics has also highlighted concerns. With respect to organic solvents, the solubility varies from 57% in ethanol to less than 0.1% in benzene. Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. Read our Privacy Notice. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. HYDROQUINONE (hahy droh kwi NOHN) is applied to the the skin to lighten areas that have darkened. Toughness of the polymer increases due to the presence of flexible units in the backbone such as long chain diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol) or long chain saturated acids (e.g., adipic . Other aspects, advantages, and modifications are evident from a review of the following claims. LSPS, Laboratoire de Spectrochimie Et Pharmacologie Structurale, University of Tlemcen, BP 119, 13000, Tlemcen, Algeria, Department of Biology, University of Ghardaia, BP 455, 47000, Ghardaia, Algeria, You can also search for this author in Skin Contact Wash off immediately with plenty of water for at least 15 minutes. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. Solubility of Hydroquinone. Solute (1 g) Water Boiling Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70 On this Wikipedia the language links are at the top of the page across from the article title. uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 The document was not able to download due to an unknown error. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. Availability. 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. Eng. 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. . New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. ORIGINAL CODE: 0009013, Ref document number: Thermodyn. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. The preferred form of protected retinol is manufactured by SunSmart (also known as Particle Sciences, Inc. of Bethlehem, PA) under the brand name of SunCaps A-1283. HVoLg~Z+ Thus, while cationic salts of acidic ascorbyl esters, preferably magnesium ascorbyl phosphate and aminopropyl ascorbyl phosphate, have beneficial antioxidant effects on the skin, the combination with hydroquinone in the invention results in a compatible and stable composition. [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. Eng. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Eastman Hydroquinone, USP, meets or exceeds the requirements of the United States Pharmacopoeia and is produced under conditions of current good manufacturing practices (cGMP). It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Magnesium ascorbyl phosphate (also called magnesium ascorbityl phosphate or magnesium L-ascorbyl-2-phosphate) has a chemical formula of C. In another embodiment, sodium metabisulfite and magnesium ascorbyl phosphate are used in about 0.01% (preferably from about 0.05% to about 0.5%, most preferably at least about 0.1%,) and about 0.5% (preferably from about 0.25% to about 3%, more preferably from about 0.25% to about 1%, and most preferably at least about 0.5%) respectively in a composition with about 4% hydroquinone. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25 K to 334.45 K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. English, J.C. and Deisinger, P.J. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. The Beaver: Its Life and Impact. 2005 Wiley-VCH, Weinheim. Data 53, 12781282 (2008), A. You can expect to hear from a technical specialist within 1 business hour. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. 0.5% magnesium ascorbyl phosphate protected at pH 6.0-7.0, 1.0-1.5% at pH 5.5-7.0, and 2.0-3.0% at pH 3.5-7.0. A3, Free format text: Recent pieces of . Eng. It is moderately soluble in water and highly soluble in alcohol. Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. This study was funded by Ministre de l'Enseignement Suprieur et de la Recherche Scientifique. Environ. Adobe Acrobat 10.1.6 Paper Capture Plug-in : Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. Hydroquinone is extensively used as a photographic developer, an antioxidant, and a stabilizing agent for readily oxidizable polymers. The solubility in water is 6.72g/L. [O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1, OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE, CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O, [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate, [Na+]. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. HYdroquinone can be found in various skin care products. This complex dissolves in hot water, where the two molecules dissociate in solution. [32], Hydroquinone is thought to be the active toxin in Agaricus hondensis mushrooms. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. Anal. Some documentation and label information may refer to the legacy brand. Editor's Rating: [33], Hydroquinone has been shown to be one of the chemical constituents of the natural product propolis. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. A specific embodiment of the invention is listed in the following table. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. protecting the retinoids in a protective system; mixing the hydroquinone, and the protected retinoids; and. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. All Rights Reserved, View All Eastman Hydroquinone USP Articles. PubMedGoogle Scholar. J. STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN. The experimental solubility data was well-correlated with the data, calculated by . Ferulic acid 0.5% 0.15g. The information given is designed only as a guide for safe handling and use. 77, No. HlRMo0WB:NnVCnE4(i0 (1* )@NzHR!>i;8XaXnsO0LNT0l$B%"NAb0I9V *6/-\vn0W"fKF:AAgl:psRZ?k`&eB IUQ0ET;W#vL=@XwRG{-LHlTz]^s%OB(GF 11'I Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. Rev. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. By clicking Accept, you consent to the use of cookies. sulfur acids, imidic, hydrazonic, hydroximic acids, Carboxylic acids, e.g. AzA inhibits tyrosinase. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Hydroquinone[1] Idrochinone Quinol 1,4-Dihydroxybenzene p-dihydroxybenzene p-hydroxyphenol 1,4-Hydroxy benzene Identifiers CAS Number 123-31-9 Y 3D model (JSmol) Interactive image Beilstein Reference 605970 ChEBI CHEBI:17594 Y ChEMBL ChEMBL537 Y ChemSpider 764 Y DrugBank DB09526 ECHA InfoCard 100.004.199 EC Number 204-617-8 Gmelin Reference 2742 By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. C6H4O2) is formed. Remove contact lenses, if present and easy to do. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. Chem. Mobility in soil No additional information available 12.5. Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. These reactions release free oxygen and generate enough heat to bring the mixture to the boiling point and vaporize about a fifth of it, producing a hot spray from the beetle's abdomen. It is found in wheat, rye, and barley.It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. Hydroquinone is sold by chemical suppliers. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. The FDA had classified hydroquinone in 1982 as a safe product - generally recognized as safe and effective (GRASE), however additional studies under the National Toxicology Program (NTP) were suggested in order to determine whether there is a risk to humans from the use of hydroquinone. Some documentation and label information may refer to the legacy brand. Have an order or account question? Hope it helps 6 yrs later.
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