and our Mild headache during a single stimulation session was reported once by an rtACS-subject and once by a sham-subject. During the treatment phase three subjects dropped out because of medical conditions that were unrelated to study participation. Fluctuations of the mean fixation positions at BASELINE, POST and FOLLOW-UP are shown as 1SD. FOLLOW-UP comparisons were calculated separately for each treatment arm using Wilcoxon matched-pairs signed rank tests. Eyes with intact vision or complete blindness were not considered. I was very impressed with the professional care that I received at the Clinic. All subjects were seated in a dimly lit room and instructed to keep their eyes closed during the whole recording session. Jeli Twj znajomy dokona wpaty za pomoc udostpnionego przez Ciebie linku, wpata ta zostanie dodana do Twoich statystyk. Power-spectra at occipital sites O1 and O2 were assessed with Fast Fourier Transformation (FFT) to determine bandwidth specific power (V2) with automatic artifact-rejection (min/max allowed amplitude: 75.00V), normalized power-spectra and DC-correction during FFT-averaging. Fedorov restorative therapy is restoring the functionality of the remaining retinal cells and optic nerve fibres. This is the case when, for example, general cell loss occurs during normal aging with specific vulnerabilities of the brains visual system structures . Click through the PLOS taxonomy to find articles in your field. Fedorov Restoration Therapy A friend of mine has found this clinic in Berlin called the Center for Vision Restoration, run by a Dr Anton Fedorov. here. However, the draw-back of this kind of sham procedure is that a minimal dose may actually have some, albeit small, therapeutic effects that cannot be separated from possible placebo effects of the current study design. For more information about PLOS Subject Areas, click (B) Individual change in HRP VF charts at BASELINE and POST in the two best responding patients of both groups. In the first trial a mean percentage increase of 65.61 104.35 was observed in the rtACS-group and 16.93 31.22 in the sham-group . Contributed reagents/materials/analysis tools: CG MB AM SS MD. Results are given as medians and 95%-CI. On a systems level, the brain, by releasing stress hormones influence vascular tone, particularly in and around the optic nerve and thereby impair vascular autoregulation and perfusion of the whole body, including itself and that of the eyes . Concerning autonomic activity, we did not observe meaningful changes induced by rtACS (pre-session rtACS values: systolic pressure 131.541.94mmHG, diastolic pressure 82.81 1.72 mmHg, heart rate 72.82 1.02, post-session rtACS values: systolic pressure 129.19 2.94 mmHg, diastolic pressure 82.20 1.24 mmHg, heart rate 70.69 0.99; means and SEM). 1.52 of visual angle both horizontally and vertically, which is in the expected range [17]. https://doi.org/10.1371/journal.pone.0156134.s003. Anton FEDOROV | Senior Researcher | Dr. (Staatl. Med. Univ. St I am very hopeful to see better with my right eye in time as well. What is stem cell therapy (regenerative medicine) and how does it work? Coherence was calculated for each pair of channels ij and defined as follows: In this equation S denotes the spectrum of signals from two EEG channels i and j, for a given frequency bin f. Changes in spectral power of oscillatory brain activity and strength of functional connectivity over the visual cortex after the first stimulation session were then related to the primary outcome measure. One serious adverse event with subsequent hospitalization occurred, but it was unrelated to rtACS. https://doi.org/10.1371/journal.pone.0156134.t003. To determine whether changes of visual field results are related to, or could be explained by, altered fixation behavior during visual field testing, HRP visual fields were measured while eye movements were recorded with an eye-tracker (Tobii ET1750, Tobii Technology AB, Sweden) in one study center (Magdeburg). VF improvement in static measures was associated with increased vision-related QoL and subjective visual functioning in patients with binocular vision impairment. Mental health in Germany: services and support | Expatica However, considering that phosphenes may contribute to a placebo effect, it cannot be ruled out that patients in the rtACS-group who experienced more significant visual phenomena during stimulation might have had a greater feeling of that a powerful treatment was occurring than those who only experienced a flash once a minute. rtACS was conducted with frequencies between 825 Hz. Three studies associated tDCS with training (vision restoration therapy) in hemianopic patients (Plow et al . full function, partial function and absolute vision loss) were determined by superimposing repeated HRP measures to determine which visual field regions are intact, partially damaged (residual I and residual II) and absolutely impaired (absolute defect). The sample size calculation was based on results of two earlier pilot studies at the Institute of Medical Psychology considering similar patients and equivalent stimulation schemes, i.e., rtACS- and sham-groups as in the present trial. Mean fixation was within the central area of 1 horizontally and 0.5 vertically for both groups at all time points (S1 Fig). In a darkened room, the patient was viewing a 17" monitor from a chin-head-rest at a distance of 42 cm. Ein weiterer Messwert, der vor allem bei Glaukom-Patienten wichtig sein kann, ist der . In the sham-group there was a significant increase in the NEI-VFQ general health and mental distress scale (p = 0.01) at POST with no significant difference between groups (p = 0.30). In the intervention-related questionnaire, the items treatment was helpful, increased vision after treatment at POST, and satisfied with treatment, general perception at FOLLOW-UP were more frequently answered positively after rtACS than after sham (S3 Fig). Our findings of improved visual functions are consistent with the hypothesis that rtACS can modulate perceptual thresholds in areas of residual vision as previously reported in studies that also used current stimulation [12, 1416] or behavioral vision training methods [10, 17, 2628]. It is the next chapter in organ transplantation and uses cells instead of donor organs, which are limited . 10.1016/B978--444-53355-5. . The FOLLOW-UP diagnostic assessment was conducted after a therapy-free interval of at least 2 months. Secondary analyses revealed improvements of near-threshold visual fields in the central 5 and increased thresholds in static perimetry after rtACS and improved reaction times, but visual acuity did not change compared to shams. Department of Neurology, Charit-Universittsmedizin Berlin, Berlin, Germany, Affiliation The following criteria were established prospectively. Their clinic is in Berlin and has been operational for about 4 years (Not long I know, but long enough that they surely would have been shut down if they were a scam). Centre for Vision Restoration was founded to deal with disorders of vision and aims to help visually impaired patients to regain or improve their eyesight. Most of the clinics are located near parks. Here, rtACS-patients reported a significant increase in NEI-VFQ visual field defect and related impairments scale (p<0.01) at FOLLOW-UP with no significant difference between groups (p = 0.40). Nervous system degeneration in aging can affect the structure and function anywhere along the visual eye-to-brain axis . According to the German Association for Psychiatry, Psychotherapy, and Psychosomatics, almost 28% of Germany's adult population is living with a mental health condition as of 2023. No, Is the Subject Area "Electroencephalography" applicable to this article? In order to analyze which areas of the visual field respond with improvements after rtACS, we separately analyzed different visual field states based on HRP measurements and developed a treatment outcome prediction model to predict from the BASELINE results of HRP visual fields the extent of vision restoration . Alternating Current Stimulation for Vision Restoration after Optic Data requests may be sent to imp@med.ovgu.de. In other words, despite lower overall alertness, visual processing to (smaller) visual stimuli was faster. Fedorov Restoration Therapy is an interdisciplinary approach that combines the sciences of Ophthalmology and Neurology. We conducted a multicenter, prospective, randomized, double-blind, sham-controlled trial in an ambulatory setting with daily application of rtACS (n = 45) or sham-stimulation (n = 37) for 50 min for a duration of 10 week days. Informed written consent was obtained prior to randomization. Current flow simulation indicates current in the frontal cortex, eye, and optic nerve and in the subcortical but not in the cortical regions. It's also extremely difficult to remove bad reviews (Which I'm sure they would have had if what they were selling snake oil). Competing interests: The authors have declared that no competing interests exist. Also Check: Lasik Vision Centers Of Cleveland. Primary and secondary endpoints were defined prospectively. The proposed mechanism of action is neuromodulation of oscillatory brain activity towards a more synchronized EEG via entrainment of specific stimulation frequencies [1011], and the reorganization of brain functional connectivity networks [12] is considered to be a novel and promising avenue for visual rehabilitation [13]. To make sure Fedorov Restoration Therapy can be of benefit, we need to learn more about you. Theyve given me hope. Attentional cueing improves vision restoration therapy in patients with visual field defects. alternating current stimulation; CSF, Transcranial direct current stimulation (tDCS) and alternating current stimulation (ACS) of the brain are new methods to modify brain excitability and synchronicity in healthy subjects and patients with brain injuries affecting different modalities such as the motor [5], language [6], or somatosensory domains [7]. Performance in these tests remained largely unchanged in both groups. We performed computer simulation to estimate the amount of current that was being delivered to components of the visual system in a 40-yrs old male control subject. Patients were assigned to either the rtACS- or the sham-group by Randomization In Treatment Arms software with stratified block randomization considering the study center and the VF defect depth at BASELINE as potential prognostic factors. Get started on your journey of vision recovery today. In fact, performance change in HRP correlated negatively with changes in deviations from fixation during eye-tracked HRPs, i.e. Application of the optimal frequencies might improve efficacy and will also shed light on the role of specific brain oscillations in their ability to activate residual vision. The ethics committees of the participating study centers in Magdeburg, Berlin, and Goettingen approved the study, and a statistical analysis plan was filed with the lead ethics committee. Furthermore, we would like to thank Electrical Geodesics Inc. (EGI) for providing multi-modal imaging data (MRI and CT images) to generate a volume conductor model to simulate rtACS. Henrich-Noack P, Fedorov A, Gall C. Vision restoration after brain and retina damage: the "residual vision activation theory". Stimulation current strength was 125% of phosphene threshold recorded during 5 Hz stimulation. Yes Denn bei einer dauerhaften Erhhung, wenn das Kammerwasser aus dem Auge also am Abflieen gehindert wird, kann es durch den stndigen berdruck zu Schden an der Netzhaut kommen, die sich sehr oft auf den Ansatzpunkt des Sehnervs und den Punkt des Schrfsten Sehens konzentrieren. Using these means and standard deviations in a sample size calculation for a two-sample t-test with nQuery Advisor 7.0 resulted in 41 patients per group for the first trial and 36 patients per group for the second trial. When vision loss develops in ocular diseases affecting the retina and optic nerve, this has repercussions at the level of brain processing as well. I can also see from Google Scholar that the papers have been cited multiple times. Concerning mean VF size obtained in kinetic perimetry, a clinically negligible but still significant increase was observed in both groups (median change after rtACS 4.3% [-0.3%, 11.9%]; p = 0.036, and after sham-stimulation 4.8% [-1.5%, 16.1%], p = 0.040). Dont Miss: Night Vision Security Camera System. No, Is the Subject Area "Brain damage" applicable to this article? I've Facebook stalked some of the people who left reviews and have even seen their before and after visual field test showing very impressive and promising results. Certain treatments, including intravitreal injection of antivascular endothelial growth factor, have shown considerable success in slowing disease progression and reducing the number of blind people worldwide by preventing further . (A) Patient flow for cases included in the primary outcome measure analysis. Te informacje mog dotyczy Ciebie, Twoich preferencji lub urzdzenia i s uywane gwnie w celu zapewnienia dziaania witryny w oczekiwany sposb. Due to the possibility that patients with monocular impairment may not experience a severe reduction in vision-related QoL, an exploratory subgroup analysis of patients with binocular loss, i.e., excluding those with an intact fellow eye, was conducted. The size of the absolute defect significantly decreased after rtACS when compared to sham-treated patients ( = 190.201, df = 1, p<0.0001) (S2 Fig). Fedorovs restorative therapy is an interdisciplinary approach that combines the knowledge of ophthalmology and neurology. Five subjects left the study between initial screening and BASELINE for different reasons and another five subjects were excluded due to violation of an inclusion criterion (unacceptable fluctuations between initial screening and BASELINE). Four 10mm Grass gold electrodes (SAFELEAD, Astro-Med, Inc, USA), 2 for each eye, were placed on the skin near the orbital cavity (transorbital), and biphasic square-pulses were applied in bursts (Alpha SYNC stimulator, EBS Germany). The simulation represents a quasi-static solution of the Maxwell equations and serves as an approximation for current density estimation of one time sample during rtACS when the cathode and anode reaches its maximal current intensity value. All rights reserved. Discover a faster, simpler path to publishing in a high-quality journal. After the first rtACS session, an increase of spectral power was observed in theta, alpha and beta frequency bands in both the occipital and frontal regions. To conceal group identity, sham-patients received only one ACS burst per minute to create phosphene experiences. A finite element model was developed using multi-modal imaging data (MRI/CT) of a 40-yrs-old male. Docs in USA do not offer anything to fix it. greywindow 4 yr. ago However, this is unlikely because we ascertained stable visual field baselines before starting the treatment and the primary and secondary outcome criteria did not improve to the same extent in the sham-group which was exposed to the same number of diagnostic test repetitions. Another issue of interest is the specificity of the range of current frequencies used for stimulation.
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