how to reduce oxidative stress in sperm

Ameliorative Effects of Vitamins A, C, and E on Sperm - Hindawi Rowe, P. J. In addition, NO and superoxide which released by monocytes form peroxynitrite cause more spermatozoa damage (84, 85). Chew BP, Park JS. Rev. Hum. Cognitive stress, mindfulness, and telomeres. & Chen, C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. Many studies have indicated the improvement in sperm count and motility of asthenozoospermic and oligospermic patient after carnitine intakes (157-162). Meucci E, Milardi D, Mordente A, Martorana GE, Giacchi E, De Marinis L, et al. the contents by NLM or the National Institutes of Health. Metabolic regulation is important for spermatogenesis. Environment pollutants may be considered as one of the main source of ROS production. Sci. & Clarkson, J. S. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. World J. Mens Health 33, 143160 (2015). & Ray, U. S. Improvement of glutathione and total antioxidant status with yoga. What is oxidative stress? Effects on the body and how to reduce Saleh RA, Agarwal A, Sharma RK, Nelson DR, Thomas AJ. 4, 439445 (1998). Human spermatozoa: revelations on the road to conception. Treatment by vitamin E for 6 months can reduce the lipid peroxidation of spermatozoa and may increase the pregnancy rate in asthenozoospermic cases . However, the spermatozoa with this abnormality are immature and functionally retarded (31, 32). Steril. Molecular mechanisms regulating human sperm function. In fact, when the free radicals level increases pathologically, antioxidant activity activated to prevent ROS oxidative damage (137). International Journal of Reproductive Biomedicine. Drge W. Free radicals in the physiological control of cell function. 40, 2594 (1991). Reprod. Spermatozoa are highly vulnerable to oxidative stress owing to limited levels of antioxidant defence and a single, limited DNA-damage detection and repair mechanism. Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility. Biomed. Natl Acad. Feng, C., Song, Y., Zou, Y. Fertil. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. But overproduction of ROS in semen can affect sperm or seminal plasma antioxidant defense mechanisms and cause oxidative stress (50, 131, 132). Article 366, 18031813 (2012). Sinha, S., Singh, S. N., Monga, Y. All included studies were reviews (46), meta-analyses (one), original research studies (18) and guideline articles (one). Saleh, R. A. et al. Gynecol. 24, 32203224 (2009). New York, USA: Springer Science and Business Media; 2013. p. 6989. 13, 3844 (2007). Over production of ROS, could be due to increase the metabolic rates, and maintain hemostasis in obese men. Cell. Knzle R, Mueller MD, Hnggi W, Birkhuser MH, Drescher H, Bersinger NA. Assist. Bay, B., Mortensen, E. L., Hvidtjrn, D. & Kesmodel, U. S. Fertility treatment and risk of childhood and adolescent mental disorders: register based cohort study. The male reproductive ducts infections and inflammatory reactions can be considered as exogenous sources (119). In this article, we reviewed the free radicals actions in male reproductive system and the effects of antioxidants on oxidative stress and fertility potential of spermatozoa. Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified? Toxicol. When stimulated by FSH, the Sertoli cell initiates spermatogenesis. Agarwal A, Deepinder F, Sharma RK, Ranga G, Li J. Oxid. J. Epidemiol. Results from an imbalance between the intracellular production of free radicals and the cellular defence mechanisms. Hu, W. et al. Tollon C, Souli M, Pontonnier F, Plante P. [Prevention of sterility in spinal cord injured men]. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. As a library, NLM provides access to scientific literature. Clipboard, Search History, and several other advanced features are temporarily unavailable. Keywords: Indian J. Med. In the meantime, to ensure continued support, we are displaying the site without styles Male reproductive toxicity of bisphenol A [Chinese]. 39, 4484 (2007). Abbreviations: bp: base-pair; CAT: catalase; LPO: lipid peroxidation; MDA: malondialdehyde; MiOXSYS: Male Infertility Oxidative System; mtDNA: mitochondrial DNA; NAD(PH): nicotinamide adenine dinucleotide (phosphate); NO: nitric oxide; 8-OHdG: 8-hydroxy-2'-deoxyguanosine; ORP: oxidation-reduction potential; OS: oxidative stress; PKA: protein kinase A; PLA2: phospholipase A2; PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PUFA: poly-unsaturated fatty acid; ROS: reactive oxygen species; SOD: superoxide dismutase; TAC: total antioxidant capacity; TBA: thiobarbituric acid. Human sperm cryopreservation and reactive oxygen species (ROS) production. Mazilli et al demonstrated that, in patients with sperm culture-positive for aerobic bacteria, the superoxide anion production was high (120). This process includes internucleosomal DNA fragmentation, which, along with chromatin condensation, is considered a hallmark of apoptosis. Venkatesh, S., Kumar, R., Deka, D., Deecaraman, M. & Dada, R. Analysis of sperm nuclear protein gene polymorphisms and DNA integrity in infertile men. Biol. NY Acad. Physiological role of ROS in male reproductive system. J. Androl. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. OS results from disturbances in the intricate balance between ROS generation and elimination. Although, ROS have both physiological and pathological function, to keep this level in confident range, the human body has a system against ROS (135, 136). Overproduction of free radicals such as reactive oxygen species and reactive nitrogen species leads to oxidative stress, which is associated with the pathophysiology of various human diseases including cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer disease and Parkinson disease), rheumatoid arthritis, and ageing. The results indicated a longer duration of sperm motility at 29 . Balhorn, R., Reed, S. & Tanphaichitr, N. Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males. Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. FOIA Fertil Steril. NO, is a lipophilic molecule and it has cytotoxic effects on adjacent sperm cells. 365, 15011515 (2010). Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Cell. & McLaughlin, E. A. Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa. https://www.duo.uio.no/handle/10852/11834. Capacitation of mouse spermatozoa II Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. 1, 151154 (1999). Res. Clin. Clinical implications of oxidative stress & sperm DNA damage in normozoospermic infertile men. Paul, C. & Robaire, B. Ageing of the male germ line. Int. Genet. & Kurpisz, M. Cytokines in the blood and semen of infertile patients. Res. West, A. Nitric oxide synthase patterns in normal and varicocele testis in adolescents. Biochem. Asian J. Androl. Shen, J., Deininger, P., Hunt, J. D. & Zhao, H. 8-hydroxy-2-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer. PubMed However, regular strength training has been shown to reduce markers of oxidative stress and boosts your body's antioxidant reserves, according to a study published in the Journal of Strength and Conditioning research. Hum. Iatrogenic DNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Arcaniolo D, Favilla V, Tiscione D, Pisano F, Bozzini G, Creta M, et al. Interventions alleviating oxidative stress (OS) and sperm DNA fragmentation (SDF) may improve ICSI outcomes and reduce the chance of injecting DNA-damaged sperm into oocyte. Alkan I, Simsek F, Haklar G, Kervancioglu E, Ozveri H, Yalcin S, et al. Dinesh, V., Shamsi, M. & Dada, R. Supraphysiological free radical levels and their pathogenesis in male infertility. J. Indian Acad. FAQs from users 3.1. 200, 248254 (1992). Int. Nature Reviews Urology Pacher, P., Beckman, J. S. & Liaudet, L. Nitric oxide and peroxynitrite in health and disease. Rev. It is suggested that dysregulation of adipocytokine and ROS generation, are the causes of oxidative stress in these patients (88). 6, 163 (2016). Peake JM, Suzuki K, Coombes JS. Steril. Studies on Men's Health and Fertility. Cell. Jarow, J. P. et al. Oda SS, El-Maddawy ZK. The role of glutathione in mammalian gametes. Mechanism of action of biological antioxidants. Another option is to resort to antioxidant food supplements to reduce oxidative stress and, therefore, improve semen quality. 3, 203213 (1997). 2014, 761264 (2014). Semchyshyn, H. M. & Lushchak, V. I. in Oxidative Stress Molecular Mechanisms and Biological Effects 1546 (InTech, 2012). Keskes-Ammar, L. et al. An antioxidant that reduces oxidative stress and improves sperm motility could be useful in the management of male infertility . & Afzelius, B. Koppers, A. J., De Iuliis, G. N., Finnie, J. M., McLaughlin, E. A. Venkatesh S, Gurdeep Singh M, Prasad Gupta N, Kumar R, Deecaraman M, Dada R. Correlation of sperm morphology and oxidative stress in infertile men. Steril. Am. Toprak V, Akaln SA, cal E, avu Y, zdemir . Acta Cir Bras. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Chen Y, Foote R, Brockett C. Effect of sucrose, trehalose, hypotaurine, taurine, and blood serum on survival of frozen bull sperm. In fact, these compounds have beneficial effects on sperm parameters and developmental ability of embryos (25). BMJ 347, f3978 (2013). Steril. Gdoura, R. et al. & Aitken, R. J. Aitken, R. J. Fertil. A variety of several etiological factors including intratesticular, post-testicular, and external factors, such as alcohol, cigarette smoking, varicocele, diabetes and etc. Curr. Kosower, N. S., Katayose, H. & Yanagimachi, R. Thiol-disulfide status and acridine orange fluorescence of mammalian sperm nuclei. Aspects Med. Nat. Environmental & lifestyle factors in deterioration of male reproductive health. Biol. Studies have shown that ROS generation in cytoplasmic droplets is mediated by cytosolic enzyme, called glucose-6-phosphate dehydrogenase (G6PD), which induces high levels of ROS production during two pathways, I) nicotinamid adenine dinucleotide phosphate (NADPH) located in sperm plasma membrane and II) NADPH- dependent oxido-reductase known as diphorase located in middle piece at mitochondrial respiratory level (33-37). J. Med. Sadri-Ardekani, H. & Akhondi, M. Identification and treatment of leukocytospermia in infertile men. Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G. & Gluud, C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Prevention of oxidative stress injury to sperm. Reprod. The role of oxidative stress in postcopulatory selection Online 14, 418421 (2007). Indian J. Med. In fact, ROS, along with several factors in spermatozoa, increase intracellular cAMP which then activates protein Kinase A. J. Physiol. Biological markers of oxidative stress: applications to cardiovascular research and practice. PubMed Central Cell. Antioxidants are the agents, which break the oxidative chain reaction, thereby, reduce the oxidative stress [58, 59]). References 6. USA 107, 74557460 (2010). Effects of ascorbic acid on sperm motility, viability, acrosome reaction and DNA integrity in teratozoospermic samples. Longev. However, the spermatozoa have minimum antioxidant enzymes. Characterization of NADPH oxidase 5 in equine testis and spermatozoa. An official website of the United States government. 82, 4795 (2002). Crow, J. F. The origins, patterns and implications of human spontaneous mutation. Oliva, R. & Dixon, G. H. Vertebrate protamine genes and the histone-to-protamine replacement reaction. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Proc. What is oxidative stress and how can it affect sperm? Oxygen-derived species: their relation to human disease and environmental stress. Trummer, H., Habermann, H., Haas, J. & Allamaneni, S. The effect of sperm DNA damage on assisted reproduction outcomes. Get the most important science stories of the day, free in your inbox. 4, 398403 (1993). Role of sperm chromatin abnormalities and DNA damage in male infertility. Oxidative stress is a bodily condition that happens when your antioxidant levels are low. Tolahunase, M. et al. Mechanisms and clinical correlates of sperm DNA damage. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. In dietary supplements 3. R. Soc. Asian Pac. Androl. Kumar, S., Chawla, B., Bisht, S., Yadav, R. & Dada, R. Tobacco use increases oxidative DNA damage in sperm-possible etiology of childhood cancer. Reprod. 62, 789796 (2000). Reprod. Also, a high ROS level in chronic non-bacterial inflammation was seen (121). & Bjelland, S. Oxidative damage to purines in DNA: role of mammalian Ogg1. J. Clin. Hum. Psychoneuroendocrinology 40, 96107 (2014). 31, 8997 (2006). Actually, ROS that are produced in testis infection and epididymis are dangerous for sperm, because, antioxidant protection in sperm is low and ROS can affect these cells in a long period (129, 130). 81, 15781584 (2004). Kaliman, P. et al. Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility. Kumar, S., Murarka, S., Mishra, V. & Gautam, A. 8600 Rockville Pike Moein MR, Soleimani M, Tabibnejad N. Reactive oxygen species (ROS) production in seminal fluid correlate with the severity of varicocele in infertile men. Verma, A. B. Apoptosis in the germ line. and transmitted securely. Khosrowbeygi A, Zarghami N, Deldar Y. Nature 158, 485 (1946). Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Online 7, 6570 (2003). In fact GPX4 is able to use thiols in nuclear protein, as an alternative reductant to glutathione (58). J Transl Med. 1, 1524 (2008). Targeting oxidative stress in disease: promise and limitations of Diabetes mellitus and sperm parameters. Park J, Rho HK, Kim KH, Choe SS, Lee YS, Kim JB. 28, 10731085 (2011). But, overproduction of ROS in semen can affect sperm or seminal plasma antioxidant defense mechanisms and cause oxidative stress. In diabetic patients, we have the increase levels of ROS, and impairment of antioxidant defense capacity (92). 2013 Jul;288(1):191-9. doi: 10.1007/s00404-013-2801-4. & Aitken, R. J. Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Nat. Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic men. Sabeur K, Ball B. In addition, several studies have shown, increasing sperm DNA damage with age in fertile and infertile men (106-108). 111, 645656 (1998). & Esteves, S. C. Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Screening for bacterial pathogens in semen samples from infertile men with and without leukocytospermia. When there is an imbalance of reactive . It is approved that oxidative stress elevates sperm chromatin/ DNA damage. Kessopoulou E, Tomlinson M, Barratt C, Bolton A, Cooke I. Physiol. A free radical is an atom or molecule that is highly reactive because it contains an unpaired electron in the outer shell. Reproduction 146, 253262 (2013). Sci. 112, 303309 (2003). CMAJ 175, 495500 (2006). Thus, this study evaluated the effect of different temperatures (29, 31, 33, and 35C), pHs (4 and 8), and hypoxia (1 mgO2 L1) on sperm motility of Colossoma macropomum (tambaqui). Endocrinol. & Arakawa, H. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. (ART). Fertil. Rate of de novo mutations and the importance of father/'s age to disease risk. 79, 292300 (2003). 5, 215 (2015). Enzymatic antioxidant contains superoxide dismutase, catalase, and peroxidase that catalytically remove reactive oxygen species from biological systems. Etiologies of sperm oxidative stress - PMC - National Center for A. Biol. & Mao, X. Mutation of MTCYB and MTATP6 is associated with asthenospermia [Chinese]. Generation of reactive oxygen species in subgroups of infertile men. Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. J. Androl. Hum. Relationship between oxidative stress, varicocele and infertility: a meta-analysis. Oxidative Damage to Sperm DNA: Attack and Defense - PubMed Oxidative stress and medical antioxidant treatment in male infertility. A variety of several etiological factors including intratesticular, post-testicular, and external factors, such as . Reprod. Effect of di (n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats. Nat Rev Urol 14, 470485 (2017). J. Google Scholar. Does garlic help improve sperm motility? 15, 893914 (2014). Kodama, H., Yamaguchi, R., Fukuda, J., Kasai, H. & Tanaka, T. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients. In addition, Ha et al showed that ROS may cause damage to blood-testis barrier in varicocele patients (83). Bedard K, Krause K-H. Correlation between sperm quality parameters and seminal plasma antioxidants status. Gil-Guzman E, Ollero M, Lopez M, Sharma R, Alvarez J, Thomas A, et al. Lift Weights Exercise actually boosts oxidative stress in the short term, which may make this seem counterintuitive. Genet. Biomed Res. 160, 205218 (2002). Talebi AR, Sarcheshmeh AA, Khalili MA, Tabibnejad N. Effects of ethanol consumption on chromatin condensation and DNA integrity of epididymal spermatozoa in rat. Monogr. Med. Potential for Ginkgo biloba as a functional food [Ph.D. thesis]. J. Nutr. 24, 281291 (2003). Lipids 40, 987994 (2005). Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. 30, 10141028 (2015). Online 28, 684703 (2014). A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models. Shaha, C., Tripathi, R. & Mishra, D. P. Male germ cell apoptosis: regulation and biology. 8600 Rockville Pike 26, 145148 (1994). government site. 3.4. The endogenous ROS produces by immature sperm and leukocytes of semen (50). Med. & Pummer, K. The impact of cigarette smoking on human semen parameters and hormones. MacLeod, J. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Toxicol. Objective: To review and present the most distinct concepts on the association of reactive oxygen species (ROS) with male reproduction. Med. Reprod. PMC Scientists define oxidative stress as "an excess production of reactive oxygen species (ROS) relative to antioxidant defense." Essentially, this means your body has an imbalance between free radicals and antioxidants. Physiological ROS production in spermatozoa regulates essential functional characteristics such as motility, capacitation . Zini A, Defreitas G, Freeman M, Hechter S, Jarvi K. Varicocele is associated with abnormal retention of cytoplasmic droplets by human spermatozoa. Tan, M. et al. Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development. A. Reprod. In addition, antioxidant enzymes in sperm cannot prevent tail and acrosome membranes from lipid peroxidation. Free radicals and antioxidants in normal physiological functions and human disease. Sci. Med. Jorsaraei SGA, Shibahara H. The in-vitro effects of nicotine, cotinine and leptin on sperm parameters analyzed by CASA system. Clinical Consequences of Oxidative Stress in Male Infertility. Total antioxidant capacity in patients with varicoceles. & Rohani, L. Cadmium-induced infertility in male mice. We explain how this imbalance affects your body and ways to prevent it. PubMed Free radicals and antioxidants: a personal view. This study suggests that Coenzyme Q 10 (CoQ 10 ) in human seminal fluid, has important metabolic and antioxidant functions; and shows a direct correlation with seminal parameters (count and motility), thus exogenous administration of CoQ 10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia. 57, 265272 (2013). Dehghani F, Hassanpour A, Poost-pasand A, Noorafshan A, Karbalay-Doust S. Protective effects of L-carnitine and homogenized testis tissue on the testis and sperm parameters of busulfan-induced infertile male rats.

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