OLE extractknown as p-menthane-3,8-diol (PMD)derives from the leaves of lemon eucalyptus trees and is chemically synthesized. Document (PDF) (33 KB PDF). It derives from a hydride of a p-menthane. D282656. Refined OLE contains approximately 64% p-Menthane-3,8-diol (a mixture of the cis and trans isomers of p-menthane-3,8-diol). a trans- p - menthane - 3,8 diol (citriodiol) (cs) Biocidal active substances . Ticks are most commonly found in forest fringes, forest glades, riverside meadows and marshland, and forest plantations with brushwood and shrubbery. A corresponding patient information leaflet on insect repellent use in pregnancy is available at www.medicinesinpregnancy.org. p-Menthane-3,8-diol is made from extracts of eucalyptus plants. The final decision regarding which treatment is used for an individual patient remains the clinical responsibility of the prescriber. Reportedly present in the lemon eucalyptus plant(Eucalyptus citriodora tree), which is native to Australia, but is now cultivated in many warm places around the world. There are, however, limited data on the use of DEET in human pregnancy, especially in the first trimester. Yadegarinia, D.; Gachkar, L.; Rezaei, M.B. Close in case of consumer and professional uses). Active Ingredient. Attachment(s) Following: May 20, 2004. Arthropod Bites | AAFP [Non-Guideline] MRID 46342801. Biochemical Pesticides Branch. The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. . Gu also recommends insect repellent sprays instead of lotions which are rubbed into the skin "forcing molecules into the skin". [3], In the DEET Reregistration Eligibility Decision (RED) the United States Environmental Protection Agency (EPA) reported 14 to 46 cases of potential DEET associated seizures, including 4 deaths. Registration of OFF! Some insect repellents are not recommended for use on younger children. However, the EPA also states that citronella may irritate skin and cause dermatitis in certain individuals. 63 Page(s). Citriodiol is a naturally sourced active ingredient found in many insect repellents worldwide. All rights reserved. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. [26], Permethrin is highly toxic to cats but not to dogs or humans. Botanicals 2; EPA Reg. There are no data relating to exposure to these agents in human pregnancy, however animal studies have not demonstrated any features of maternal or developmental toxicity. Carroll SP, Loye J, 2006, Journal of the American Mosquito Control Association 22(3):507-514, 510. Risk Assessment and Mammalian Toxicology Reviews for the Registration of a New PMD, a Registered Botanical Mosquito Repellent with Deet - ResearchGate A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. A number of veterinary products for flea and tick control on domestic pets contain d -limonene from citrus peels as the active ingredient. Biochemical Pesticides Branch. Efficacy testing of several Ixodes ricinus tick repellents: different The source of the information is mentioned in the introductory sentence of the hazard statements. So I always take a look at the natural insect repellents when Im buying bug spray. Canadian researcher, Xiaochen Gu, a professor at the University of Manitobas faculty of Pharmacy who led a study about mosquitos, advises that DEET should be applied 30 or more minutes later. HAZARDS IDENTIFICATION This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200). Necessary cookies are absolutely essential for the website to function properly. Synthesis of p-menthane-3,8-diol from citronellal over lignin-derived [3], In 2015, Researchers at New Mexico State University tested 10 commercially available products for their effectiveness at repelling mosquitoes. DP Barcode D243976; Roger gardner. Facts, EPA, "Identification of the active components of garlic causing repellent effect against the rice weevil and the wheat flour beetle", "An appropriate method for extracting the insect repellent citronellol from an indigenous plant (Pelargonium graveolens L'Her) for potential use by resource-limited animal owners", "Patent Literature on Mosquito Repellent Inventions which Contain Plant Essential Oils - A Review", 10.1603/0022-2585(2006)43[731:rooole]2.0.co;2. Document (PDF) (1469 KB PDF). Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EUs mechanism for protecting the health of workers. 528/212) under its generic name "p-Menthane-3,8-diol rich botanic oil" and is currently proceeding through the registration process with the Health and Safety Executive in the UK. 3.1 Substances SECTION 4: First-aid measures 4.1 Description of necessary first-aid measures If inhaled Move the victim into fresh air. Although highly toxic to cats, permethrin is recommended as protection against mosquitoes for clothing, gear, or bed nets. Language links are at the top of the page across from the title. [69][70][71][72] Some claim that plants such as wormwood or sagewort, lemon balm, lemon grass, lemon thyme, and the mosquito plant (Pelargonium) will act against mosquitoes. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. However, some plant-based repellents may provide effective relief as well. As a consequence, REACH registration data will likewise not be updated in Infocards, Brief Profiles, the Advanced search, or the Nanomaterials on the EU market portal. Memorandum. Insects and arachnids that bite in self-defense instead of to feed -- such as yellow jackets, bees, wasps, hornets, certain ants or spiders -- cannot be repelled with insect repellents. causes serious eye damage. April 30, 2003. Russel Jones. REACH regulationaims to improve the protection of human health and the environment from the risks that can be posed by chemicals. Sheryl Reilly. P-menthane-3,8-diol is used to make products that are applied to human skin and clothing for the purpose of repelling insects, such as mosquitoes, biting flies and gnats. 44624101 through -05. 17 Page(s). Analytical cookies are used to understand how visitors interact with the website. The objective of this study was to provide an estimate of the potential for 38DIOL systemic absorption in humans. If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. This active ingredient is used to make products that are applied to human skin and clothing for the purpose of repelling insects, such as mosquitoes. When shopping for a natural mosquito repellent, oil of lemon eucalyptus is the ingredient youre looking for. Phytochemistry, 2006, 67, 12, 1249-1255, https://doi.org/10.1016/j.phytochem.2006.04.025 Comparisons explanatory text in the display: Govindarajan M., Sivakumar R. " Adulticidal and repellent properties of indigenous plant extracts against, United States Environmental Protection Agency, Learn how and when to remove this template message, "Updated Information regarding Insect Repellents", Centers for Disease Control and Prevention, "The Efficacy of Some Commercially Available Insect Repellents for Aedes aegypti (Diptera: Culicidae) and Aedes albopictus (Diptera: Culicidae)", "Insektenschutz: Wie man das Stichrisiko senkt", "Repellentien und Insektizide: Erfolgreich gegen den Insektenangriff", "Test: Mosquito Repellents, The Verdict" Choice, The Australian Consumers Association, "Protection against Mosquitoes, Ticks, & Other Arthropods", U.S. Centers for Disease Control, "Mosquito repellents that emit high-pitched sounds don't prevent bites", "Reregistration Eligibility Decision: DEET." PDF Safety Data Sheet - Scbt 8 Page(s). 34, 763. The summaries of these monographs are openly available on UKTIS.org. 4822-515), This website uses cookies to ensure you get the best experience on our websites. Roger Gardner. safe for the whole family and the environment. B. Within countries of the European Union, implementation of Regulation 98/8/EC,[24] commonly referred to as the Biocidal Products Directive, has severely limited the number and type of insect repellents available to European consumers. (no), 2-hydroxi-.alfa.,.alfa.,4-trimetylcyklohexanmetanol Below is a list of some natural products with repellent activity: Some old studies suggested that the ingestion of large doses of thiamine (vitamin B1) could be effective as an oral insect repellent against mosquito bites. DP Barcode D279876. [13] Research has also found that neem oil is mosquito repellent for up to 12 hours. Technology, Office of Data Some mosquito repellents include p-menthane-3,8-diol from mint as active ingredients and citronellal is also used in mosquito coils. 67 Page(s). Eddy & McGregor 1949 and Wiesmann & Lotmar 1949 used mice, Wasicky et al 1949 canaries and guinea pigs, Kasman et al 1953 also guinea pigs, Starnes & Granett 1953 rabbits, and many used cattle.[79]. Most natural repellents are less effective, but the best of these is oil of lemon eucalyptus, which contains the active ingredient p-menthane-3,8-diol. (It may also be labeled as p-menthane-3,8-diol, or PMD.) Freshteh Toghrol. Concentrate (EPA Reg. According to the classification provided by companies to ECHA in CLP notifications this substance is a flammable liquid and vapour and causes serious eye damage . p-Menthane-3,8-diol, also known as para-menthane-3,8-diol, PMD, or menthoglycol, is an active ingredient used in insect repellents. All rights reserved. They might smell nice, but there isnt any solid evidence that they actually work. [73], There are several, widespread, unproven theories about mosquito control, such as the assertion that vitamin B, in particular B1 (thiamine), garlic, ultrasonic devices or incense can be used to repel or control mosquitoes. Note: Where travel to a malarial area during pregnancy is unavoidable, additional prophylaxis will be necessary. 4822- (hu), 2-hidroxi-alfa,alfa,4-trimetilciclo-hexanometanol Another important use of EO components is for the fumigation of beehives . p-Menthane-3,8-diol (PMD) is gradually dethroning the synthetic golden standard mosquito repellent, N,N-diethyl-m-toluamide (DEET), as PMD is natural and considered safer while displaying an excellent repellent activity. ChEBI p-Menthane-3,8-diol is a natural product found in Myrtus communis, Litsea cubeba, and other organisms with data available. systematic names: ()-p-menthane-3,8-diol 1-hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methylcyclohexane 1-hydroxy-5-methyl-2-(1-methyl-1-hydroxyethyl)cyclohexane . Biochemical Pesticides Branch. The EC or list number is the primary substance identifier used by ECHA. This is unique source of information on the chemicals manufactured and imported in Europe. A .gov website belongs to an official government organization in the United States. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). p-Menthane-3, 8-diol smells similar to menthol and acts as a coolant. Substances listed in the EINECS, ELINCS, or NLP inventories. Personally, I go for any of the three, and dont worry about whether the label says natural or not. LEI), Containing 10% p-Menthane- diol (Chemical No. EWG researchers have analyzed the science in depth and found that, with proper application and precaution, our recommended active ingredients - Picaridin, DEET, and IR3535 - effectively reduce risk from life-altering disease and have very low toxicity concerns. (de), 2-hydroxy-,,4-trimthylcyclohexanemthanol Micro Wave: Why Mosquitoes Bite You More Than Your Friends, "Exploring the Potentiality of Natural Products from Essential Oils as Inhibitors of Odorant-Binding Proteins: A Structure- and Ligand-Based Virtual Screening Approach To Find Novel Mosquito Repellents", "Promising Aedes aegypti repellent chemotypes identified through integrated QSAR, virtual screening, synthesis, and bioassay", "A Granddad's Advice May Help Thwart Mosquitoes", "Cimex lectularius under Laboratory Conditions", "Catnip Repels Mosquitoes More Effectively Than DEET", Flower and Vegetable Oils, R.E.D. Insect repellents are agents applied to the skin, clothing and/or bed nets to deter biting insects such as mosquitos and ticks. (ro), Blanding af cis- og trans-p-menthan-3,8-diol (citriodiol) *min.64% PRODUCED BY NATURE Citriodiol is a naturally sourced active ingredient found in many insect repellents worldwide. Memorandum. Its in a lot of natural bug sprays, its EPA-registered, and studies show that it provides a similar level of protection as common DEET sprays. September 19, 2002. Others are made of nice-smelling herbs and wishful thinking. H 2 O. CAS No. Pages 49-53, 61-63 removed, registrant data. When Im out enjoying nature, it seems a little weird to spray synthetic chemicals all over my body. Usually, OLE comes as a spray but is also found in lotions.. PDF p-Menthane-3,8-diol (011550) Biopesticide Registration Eligibility Document A new Data Availability System is being developed by ECHA. [citation needed], A 2018 study found that Icaridin, is highly toxic to salamander larvae, in what the authors described as conservative exposure doses. February 04, 2005. DP Barcode D302517; MRIDs 45930401. Not intended for diagnostic or therapeutic use. Attachment(s) Following: June 29, 1999. WHO Food Additives Series No. This information is only displayed if the substance is welldefined, its identity is not claimed confidential and there is sufficient information available in ECHAs databases for ECHAs algorithms to generate a molecular structure. para-menthane-3,8-diol, 42822-86-6 - The Good Scents Company Registration of Manufacturing-Use Product (MUP) Citrodiol Insect Repellent Attachment(s) Following: June 09, 2000. Oil of Lemon Eucalyptus Mosquito Repellent - Health Why Citriodiol? - Citrefine : 2451-01-6. All DEET-containing mosquito repellents were active. Skin-Applied Repellent Ingredients | US EPA However, these electronic devices have been shown to be ineffective based on studies done by the United States Environmental Protection Agency and many universities.[16]. Memorandum. Document (PDF) (2779 KB PDF). the electronic edition of the Official Journal of the European Union. 011550) as its Active Ingredient. (continued) each containing 40% Oil of Eucalyptus (Chemical. Synthetic repellents tend to be more effective and/or longer lasting than "natural" repellents. (da), 2-hydroxy-, , 4-trimetylcyklohexnmetanol Citriodiols first-rate efficacy, providing a unique level of accreditation for a plant-based repellent. 45615201 to -05. (ro), 2-hidroxi-.alfa.,.alfa.,4-trimetil-ciklohexn-metanol (lv), 2-hidroxi-.alfa, alfa, 4-trimetilciclohexanmetanol 103 Page(s). 4822-509), Containing 10% p-Menthane-3,8-Diol (Chemical No. P menthane-3,8-diol (PMD) and picaridin (icaridin) 20% are possible alternatives to DEET containing products, although PMD should not be used where there is a risk of malaria as it may not afford an appropriate level of protection. EWG's 2018 Guide to Bug Repellents | Environmental Working Group Science Review in Support of Registration of UICK II (EPA Reg. Danger! p-Menthane-3,8-diol - Regulatory Actions | Chemical Search | Pesticides Index | Jobs, Science Reviews Previously Released under FOIA. This article was originally published on April 9, 2019 and was updated June 2021 to reflect current style. Unknown. It is colorless. Please click here to see any active alerts. Document (PDF) (1729 KB PDF). Document (PDF) (1343 KB PDF). Identity p-Menthane-3,8-diol Technical, formerly submitted as Granola 97, is an insect repellent manufacturing use product that consists of p-methane-3,8-diol as the active ingredient. P-MENTHANE-3,8-DIOL - National Center for Advancing Translational Sciences We expect the first version to be publicly available by the end of 2023. [1][2][8] Essential oil repellents can be short-lived in their effectiveness. Plant-based insect repellents: a review of their efficacy, development DP Barcode D277629; MRIDs 45468301, 45488101, -02, -03. But opting out of some of these cookies may affect your browsing experience. We may earn a commission from links on this page. Submission of Amended Efficacy Studies. Find out more on how we use cookies. P-menthane | Sigma-Aldrich - MilliporeSigma Avoid sprays that just have botanical ingredients, like blends of essential oils, geraniol, and others. Biochemical Pesticides Branch. (hu), Gemisch aus cis- und trans-p-Menthan-3,8-diol (Citriodiol) ChEBI: P-menthane-3,8-diol is a p-menthane monoterpenoid in which p-menthane carries hydroxy groups at C-3 and C-8. System of Registries | US EPA Containing 10% p-Menthane-3,8-Diol (Chemical No. (lt), Cis- ja trans-p-mentaan-3,8-diooli segu (tsitriodiool) Response to SC Johnson Email Dated April 22, 2003 Regarding UICK-T (EPA File p-menthane-1,8-diol CAS Number: 80-53-5 Molecular formula: C10H20O2 IUPAC Name: 4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol. Biochemical Pesticides Branch. WPC Brands; Case No. Registration of Granola 97 (EPA File Symbol 4822-UOO) Containing 99% p- (p-Menthane-3,8-diol) DATE PREPARED: 7/10/2017 Page 1 of 11 Section 1. April 18, 2002. [9], A test of various insect repellents by an independent consumer organization found that repellents containing DEET or picaridin are more effective than repellents with "natural" active ingredients. It is also a major breakdown product of menthol, 12 the alcohol in mint oils used as peppermint flavoring. Document (PDF) (132 KB PDF). However, other risk factors may be present in individual cases which may independently increase the risk of adverse pregnancy outcome. Document (PDF) (558 KB PDF). Only a small number of active ingredients have been supported by manufacturers in submitting dossiers to the EU Authorities. Substance Information - ECHA [1][2], For protection against mosquito bites, the U.S. Centers for Disease Control (CDC) recommends DEET, picaridin (icaridin, KBR 3023), oil of lemon eucalyptus (para-menthane-diol or PMD), ethyl butylacetylaminopropionate and 2-undecanone with the caveat that higher percentages of the active ingredient provide longer protection. To begin with this system will take over the responsibility of making REACH registration data available, once it is ready. P-menthane-3,8-diol - University of Hertfordshire JavaScript appears to be disabled on this computer. Safety evaluation of certain food additives prepared by the sixty-third meeting of the Joint FAO/WHO Expert Committee on Food Additives (JEFCA). on behalf of the United States of America. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. The exception to this is para-menthane 3, 8 diol, which has a lower vapour pressure than volatile monoterpines found in most plant oils and provides very high protection from a broad range of insect vectors over several hours , whereas the essential oil is repellent for around one hour .
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