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Structural formula Name CAS Reactants; Bisphenol AF: 1478-61-1: Phenol: Hexafluoroacetone: Bisphenol F: 620-92-8: Phenol: At last,Bisphenol A epoxy resin() safety, risk, hazard and . About 6570% of all bisphenol A is used to make polycarbonate plastics,[9][10] which can consists of nearly 90% BPA by mass. It is commonly used in curing fast-drying epoxy resin adhesives. The results of the CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirm BPAs safety. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. [34] These are not always removed and are known impurities in commercial samples of BPA. Food cans and other metal containers may be coated with epoxy resin linings made with BPA to help prevent direct food contact with metal, which helps protect food from contamination and spoilage. Toxicol Lett. [28] BPA was never used as a drug. BISPHENOL A DIGLYCIDYL ETHER RESIN Chemical Properties,Uses,Production Introduction Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). How does BPA get into the body? [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : For more chemical safety facts, follow us on social media. When the number-average molecular weight is less than 400, the main component is bisphenol A diglycidyl ether (DGEBA, relative molecular weight 340). This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. BPA can also be found in breast milk. Rapid Commun Mass Spectrom. Bisphenol-A, commonly abbreviated as BPA, is an organic compound with the chemical formula (CH 3) 2 C (C 6 H 4 OH) 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. In recent years, many claims have been made about the health effects of BPA. In the United States, FDA is the agency charged with this review for food contact applications. Demonstrated that oral BPA administration results in rapid metabolism of BPA to an inactive form. 2011 Nov 15;257(1):122-36. i) Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. The subchronic study was designed to characterize potential effects of BPA in a wide range of endpoints, including prostate and mammary glands, metabolic changes, and cardiovascular endpoints. Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications, 31 October 2008. Chemical name Common names and synonyms CAS number EC number Concentration; 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane: At that time, another synthetic compound, diethylstilbestrol, was determined to be more powerful than estrogen itself, so bisphenol A was not used as a synthetic estrogen. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. This early work underpinned the development of epoxy resins, which in turn motivated production of BPA. To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. Toxicol Appl Pharmacol. PA is also used in the production of epoxy resins. At 830C). (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. Di- and polyols lead to . [105] As such, the precise effects of BPA on the growth, reproduction, and development of aquatic organism is not fully understood. You may have heard claims that BPA exposure causes health effects in people. Dianin in 1891. [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. In addition to the FDA review process, FDAs Acting Chief Scientist asked five expert scientists from across the federal government to provide independent scientific review of these documents in the fall of 2009. [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). Bisphenol A (BPA) is a chemical used to make polycarbonate plastic. Released in 2018 by the U.S. National Toxicology Program, the data supports FDAs one word answer to the question Is BPA safe?: Yes. . It belongs to the phenol class of aromatic organic compounds. BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 6570% of all BPA production. An amendment of the food additive regulations based on abandonment is not based on safety, but is based on the fact that the regulatory authorization is no longer necessary for the specific use of the food additive because that use has been permanently and completely abandoned. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. BPA seems to bind strongly to ERR- (dissociation constant = 5.5 nM), but only weakly to the ER. . The site is secure. Polym Adv Technol 2009; 20: 194-208. . BPA has been used in food packaging since the 1960s. [22] BPA-free plastics have also been introduced, which are manufactured using alternative bisphenols such as bisphenol S and bisphenol F, but there is also controversy around whether these are actually safer. BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . Toxicol Sci. The condensation of acetone (hence the suffix 'A' in the name)[32] with two equivalents of phenol is catalyzed by a strong acid, such as concentrated hydrochloric acid, sulfuric acid, or a solid acid resin such as the sulfonic acid form of polystyrene sulfonate. Toxicol Appl Pharmacol. 1). Search for free and find new suppliers for chemical products, pharmaceuticals and APIs. [33] An excess of phenol is used to ensure full condensation and to limit the formation of byproducts, such as Dianin's compound. FDA will continue to participate in discussions with our international regulatory and public health counterparts who are also engaged in assessing the safety of BPA. [7] Thus, in bisphenol F, the F signifies formaldehyde. In addition, FDA actively supported and participated in the Expert Consultation on BPA convened by World Health Organization and the Food and Agriculture Organization of the United Nations on November 2-5, 2010, in Ottawa, Canada. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. The epoxide resins (also widely known as epoxy resins and, occasionally, as ethoxyline resins) are characterised by the possession of more than one 1,2-epoxy group (I) per molecule. In particular, infants are considered to be at greater risk,[83] leading to bans on the use of BPA in baby bottles and related products by the US,[84] Canada,[85] and EU[86] amongst others. Federal government websites often end in .gov or .mil. 08-5994, September 2008. In recent years, DGEBA has been used for the inner coating of packaging materials such as canned food. [103], BPA is an environmental contaminant of emerging concern. [15] Although the effect is very weak,[16] the pervasiveness of BPA-containing materials raises concerns, as exposure is effectively lifelong. 40:35-40. Update on Bisphenol A (BPA) for Use in Food Contact Applications, January 2010; March 30, 2012; Updated March 2013; July 2014; November 2014. In 2008 FDA released a document titled Draft Assessment of Bisphenol A for Use in Food Contact Applications. Farbenindustrie reported the coupling of BPA and epichlorohydrin. Every day, people are exposed to a variety of activities or products that could, under certain circumstances, cause harm. While there have been many hundreds of studies on BPA, none has shown a direct cause-and-effect relationship between BPA and any human health effects. . 2010 Oct 30;24(20):3011-20. n) Yang X, Doerge DR, Fisher JW. The chemical formula of Bisphenol A is C15H16O2. 2011 Sep 15;255(3):261-70. e) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Its current uses are as a primary monomer in polycarbonate plastic and epoxy resins. Phenol is a man-made chemical, although it is also found naturally in animal waste and decomposing organic material. we live in today. PubChem CID 24754; . Bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2.BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. [36] It may be purified by recrystallisation from acetic acid with water. MAIN APPLICATIONS Bisphenol A Epoxy is widely used in the manufacture of: Epoxy resins; Phenolic resins . Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2.It has two phenol functional groups on either side of a sulfonyl group. Bisphenol A is a chemical compound containing two phenol functional groups. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. Although it is 1000- to 2000-fold less potent than estradiol, the major female sex hormone in humans. Before sharing sensitive information, make sure you're on a federal government site. The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. These materials are much more common but their BPA content will be low. FDA has amended its regulations to no longer provide for the use of BPA-based polycarbonate resins in baby bottles and sippy cups. Among the various polymers available as resins for composites [26][27][28][29][30][31], epoxy resins are chosen because of their excellent adhesion to many substrates and their high thermal and . [2]FDA Science Board Subcommittee on Bisphenol A. This compound is synthesized by the condensation of acetone with phenol. Bisphenol A is an organic synthetic compound used in formulating plastics and epoxy resin. Epoxy vinyl ester resins (VER), Often shortened to vinyl esters, are an important class of high-performance thermoset molding resins. Some of these studies have raised questions about the safety of ingesting the low levels of BPA that can migrate into food from food contact materials. [17] Although BPA exposure is common it does not accumulate within the body, with toxicokinetic studies showing the biological half-life of BPA in adult humans to be around two hours. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. But, lets first start by understanding thermosets. Some are conducted according to internationally recognized standards that ensure methodological and statistical reliability, and others are not. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. Due to its especially thick natural consistency, there will commonly be additives and diluents which are added into the Bisphenol-A epoxy formula to enhance workability and adhesion. [95] BPA in sediment degrades most slowly of all, particularly where this is anaerobic. Products made from BPA meet high-performance demands. If you are giving a presentation about an environmental health topic or Bisphenol Resin. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. [106][107] BPA appears able to effect development and reproduction in a wide range of wildlife,[107] with certain species being particularly sensitive, such as invertebrates and amphibians.[106]. BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. 80-05-7 Bisphenol a with Wholesale Price Min. Chemical Economics Handbook. The original approvals for BPA were issued under FDAs food additive regulations and date from the 1960s. (sometimes called a dimer) is called bisphenol F, which is an important monomer in the production of epoxy resins. Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application . Chemical Identity. Dianin in 1891. Order: 18 Tons Shandong Near Chemical Co., Ltd. View larger video & image Contact Now Hot Sale Bisphenol a CAS No. Toxicol Sci. Epoxy resins are made by reacting epichlorohydrin (ECH) and bisphenol A to produce a different chemical substance called bisphenol A diglycidyl ether (also known as BADGE or DGEBA). BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. 25085-99-8) Suppliers Limit companies to: Worldwide USA China India EMAIL INQUIRY to 13 suppliers BOC Sciences | Address: Ramsey Road, Shirley, New York 11967, USA https://www.bocsci.com | Send Inquiry | Phone: +1- (631)-485-4226 BOC Sciences is a brand of BOCSCI Inc. The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. [27], In terms of the endocrine disruption controversy, the British biochemist Edward Charles Dodds tested BPA as an artificial estrogen in the early 1930s. Toxicol Appl Pharmacol. . On the regulatory front, FDAs regulations authorize FDA to amend its food additive regulations to reflect when certain uses of an additive have been abandoned. This results in much lower internal exposure of BPA (i.e., the active form) than what occurs from other routes of exposure such as injection. Neurotoxicol Teratol. NIEHS provides many opportunities for funding to individual researchers, organizations, and businesses. Copolymer epoxy resins were prepared using a two-step process in which 10, 30 and 50% of bisphenol-A was replaced with liquefied bamboo. BISPHENOL A EPOXY: is solid at room temperature, in the form of prills, white - peal, white to yellow and with a slight phenolic odour. FDA can take this action on its own initiative or in response to a food additive petition that demonstrates that a use of a food additive has been permanently and completely abandoned. 2012 Jun 1;211(2):114-9. g) Doerge DR, Twaddle NC, Woodling KA, Fisher JW. 2013 Jul 1;270(1):45-59. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Epoxy resin is based on epichlorhydrin and bisphenol A. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). Usage/Application: Polycarbonate , Epoxy resin, Thermal paper. Learn how outdoors and chemistry work together. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. The epoxide functional group is also collectively called epoxy. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food and drink containers, and many other products. Product. [1]U.S. Food and Drug Administration, Draft Assessment of Bisphenol A for Use in Food Contact Applications, 14 August 2008. Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. [12][13][14] BPA is a xenoestrogen, exhibiting hormone-like properties that mimic the effects of estrogen in the body. [98] Despite its short half-life and non-bioaccumulating character, the continuous release of BPA into the environment causes continuous exposure to both plant[104] and animal life. Phenol-formaldehyde resin . Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity, similar to glass. FDA will update its assessment of BPA and will take additional action if warranted. With more than half of the global demand, the Asian market will . All rights reserved, 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane],homopoly, 4,4-(1-methylthylidene)bisphenol,polymerwith2,2-[(1-methylethylidene)bis(, Poly(Bisphenol A-co-epichlorohydrin) average Mw ~40,000, pellets, 4-(1-methylethylidene)bisphenol,-polymerwith(chloromethyl)oxirane, bis(4,1-phenyleneoxymethylene)]bis[oxirane], diglycidyletherofbisphenola-basedepoxyresins,lowmolecularweight, lowmolecularweightliquiddgebpa-basedepoxyresins, lowmolecularweightsoliddgebpa-basedepoxyresins, Phenol,4,4-(1-methylethylidene)bis-,polymerwith(chloromethyl)oxirane, phenol,4,4-isopropylidenedi-,dimerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,monomerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,polymerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,tetramerwith1-chloro-2,3-epoxypropane, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin condensate, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin copolymer, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin polymer, 2,2-Diphenylolpropane-epichlorohydrin polymer, 4,4'-ISOPROPYLIDENEDIPHENOL/EPICHLOROHYDRIN COPOLYMER, 4,4-ISOPROPYLIDENEDIPHENOLEPICHLOROHYDRINRESIN, PHENOL44METHYLETHYLIDENEBISPOLYMERWITHCHLOROMETHYLOXIRANE, Reaktionsprodukt aus Bisphenol-A oder -F mit Epichlorhydrin (Molekulargewicht <700, Gehalt an freiem Epichlorhydrin <20 ppm, nicht in R40 oder R45 eingestuft), reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecular weight 700), bisphenol A/ epichlorohydrin resin, solid, bisphenol A/ epichlorohydrin resin, liquid, BISPHENOL A DIGLYCIDYL ETHER RESIN structure, EPICHLOROHYDRIN-4,4'ISOPROPYLIDENEDIPHENOL RESIN, Bisphenol A epichlorohydrin polymer (25068-38-6), P201-P273-P280-P305+P351+P338-P310-P333+P313-P337+P313-P391, 36/38-43-51/53-42/43-63-62-36/37-20/21/22-45-23/24/25, BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers, BISPHENOL A DIGLYCIDYL ETHER RESIN(25068-38-6)FT-IR, TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III), 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol, 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol: 2-methyloxirane, 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol, Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, monoesters with C18-unsatd. By 2009, FDA released reassessments of studies cited in the NTP Monograph in addition to other relevant studies that became available after the Monographs release. The molecular weight and the epoxy equivalent weight are controlled by the ratio of epichlorohydrin EPC:BPA. If youve ever read a news article or blog post about chemicals, you may have heard the oft-cited claim that there are 84,000 chemicals in commerce but only 200 of these have been tested for safety. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. [5] Although the reassessments indicated a need to further evaluate a number of endpoints or biological outcomes, the analyses did not recommend any adjustments to BPA levels reported in food at that time. BPA is a structural component in polycarbonate beverage bottles. [42] This process converts the individual molecules of BPA into large polymer chains, effectively trapping them. 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. Information about this expert consultation and the report of the meeting is available from the WHO web site. A large number of ketones undergo analogous condensation reactions. BPA is fairly cheap to produce, as the synthesis benefits from a high atom economy and large amounts of both starting materials are available from the cumene process. . BPA can both mimic the action of estrogen and antagonise estrogen, indicating that it is a selective estrogen receptor modulator (SERM) or partial agonist of the ER. Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. Using the data and design from the rodent subchronic study, the National Toxicology Program/Food and Drug Administration (NTP/FDA) is conducting a long-term toxicity study of BPA in rodents to assess a variety of endpoints, including novel endpoints where questions have been raised. Bisphenol-A Based Epoxy Vinyl Ester Resins Home Bisphenol-A Based Epoxy Vinyl Ester Resins VE resins are a combination of both polyester resin and epoxy resins best properties. It is also known to exhibit strong endocrine-disrupting ability. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. View our page to search various areas of interest and methodology. [12] While normal exposure is below the level currently associated with risk, several jurisdictions have taken steps to reduce exposure on a precautionary basis, in particular by banning BPA from baby bottles. [73] Concern is mostly related to its estrogen-like activity, although it can interact with other receptor systems as an endocrine-disrupting chemical. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. [8], Usually, the addition of acetone takes place at the para position on both phenols, however minor amounts of the ortho-para (up to 3%) and ortho-ortho isomers are also produced, along with several other minor byproducts. 12 oz. There is some evidence that BPA exposure in infants has decreased as a result of this. It belongs to the phenol class of aromatic organic compounds. Developed physiologically based pharmacokinetic models that can be used to predict the level of internal exposure to the active and inactive forms of BPA. Products like bike helmets, police shields, reading glasses and bullet-proof glass are all shatter resistant because of BPA. [28], The synthesis of BPA still follows Dianin's general method, with the fundamentals changing little in 130 years. Physical State: Powder. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. On this Wikipedia the language links are at the top of the page across from the article title. Bisphenol A Epoxy Resin (CAS No. Toxicol Sci. just looking for general information about environmental health research or the institute, this page will help. Bisphenol F (BPF) based epoxy resins are more flexible than that of BPA-based epoxies. #12-03 Keck Seng Tower, Singapore 069535, 6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane, BPA. 2012 May-Jun;34(3):331-7. l) Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. The method is a modification of NIOSH P&CAM Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. Use the browser controls to adjust the font size, or print this page. Supplier. These studies also addressed questions about how long it takes for the body to dispose of BPA. The 2003-2004 National Health and Nutrition Examination Survey (NHANES III) conducted by the Centers for Disease Control and Prevention (CDC) found detectable levels of BPA in 93% of 2517 urine samples from people six years and older. The study orally dosed pregnant rodents with 100-1000 times more BPA than people are exposed to through food, and could not detect the active form of BPA in the fetus 8 hours after the mother's exposure. As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. Recently completed a rodent subchronic study [7] intended to provide information that would help in designing a long-term study that is now underway (see below). The performance represented by each part of the Bisphenol A-type epoxy resin is shown here: Araldite? The next question is how do you make epoxy resin. These plastics first appeared in 1958, being produced by Mobay, General Electric, and Bayer. For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers. Lactational transfer of bisphenol A in Sprague-Dawley rats. Pathways include photo-oxidation, or reactions with minerals such as goethite which may be present in soils and sediments. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. This is called a two-step method. read more. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. [48] BPA is a major component of several high-performance plastics, the production of these is low compared to other plastics but still equals several thousand tons a year. This group may lie within the body of the molecule but is usually terminal. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Bottle producers have largely switched from polycarbonate to polypropylene and there is some evidence that BPA exposure in infants has decreased as a result of this. 2005 2022 American Chemistry Council, Inc. Reports indicate that it is a minor skin irritant as well, although less so than phenol. As is the case when foods are in direct contact with any packaging material, small, measurable amounts of the packaging materials may migrate into food and can be consumed with it. To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. [4] http://www.regulations.gov/document/FDA-2010-N-0100-0006. In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. NIEHS intramural scientists have defined descriptive terms of particular relevance to their own research, and have ranked those terms accordingly. NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. Another reason for concern, especially for parents, may be because some animal studies report effects in fetuses and newborns exposed to BPA. The remaining 5% of BPA is used in a wide range of applications, many of which involve plastic. [22][17][72], The health effects of BPA have been the subject of prolonged public and scientific debate,[12][13][14] with PubMed listing more than 16,000 scientific papers as of 2022. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. 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