People who are obese are more likely to age faster, die younger, and have a variety of health problems. As they lost weight and mass they didnt need to use as much energy to move around and run their bodies (their resting metabolic rate dropped). Growing up, however, she found herself transitioning to non-fiction, psychological, and self-help books. He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School. Now to exercise. I have hit a plateau which I am familiar with. For a more thorough review of that research consider reading the book Spark by Dr. John Ratey. David Sinclair ingests 500 mg to 1,000 mg of resveratrol in the morning on an empty stomach after dissolving it with a bit of Greek yogurt or olive oil. Dr. Sinclair dissolves 1000mg of Resveratrol in olive oil and drinks it every morning. Lots of work to keep me busy here, but I still need to exercise. When the telomere runs out, the cell stops dividingleading to many of the problems of old age. He explains that diseases like type I diabetes, multiple sclerosis (MS), and even cancer benefit from fasting. RELATED READING: Dr. Rhonda Patricks Fish Oil Protocol & Brand, Dr. Sinclair recommends that people who want to quit smoking should try natural nicotine replacement therapy instead of smoking, which actually increases craving. Too much cold exposure leads to frost bite and tissue damage. [Learn More. Great article for those of us that are not deep into the scientific community. may increase insulin sensitivity, and energy levels, and sharpen your mind. Intermittent Fasting Is A Method Of Calorie Restriction So Is Sleep. Your email address will not be published. Also water and coffee are typically not counted in most fasting programs. Ive been a big proponent of breathing during exercise-breathing every 20 seconds, says Dr. Sinclair, who adds that he stays in good shape by running three miles every morning. It is suitable for athletes or bulking up, but when looking at the evidence, high protein, carnivorous, red meat-based diets are not beneficial for a longer lifespan. To me that sounds like the ultimate vacation! Try no breakfast or lunch for two weeks. It should get easier (your hunger should go away) by the end of the two weeks, as your body adapts. Another benefit is that it makes you full more easily as extracted thylakoid reduces appetite. I spent about 20 years doing martial arts and 40+ years in construction. Vitamin C is necessary for the synthesis of collagen which is the most abundant protein in our bodies. 3. This article will be shared with my group and will give you and the researchers props!. Fasting on a quarterly basis Remain hungry for a complete week every 3 months. All rights reserved. I have been doing Intermittent fasting since 2017, And I could say it really did changed my lifestyle. (0:21:24) Evidence that Fasting is a Pro-longevity Intervention in Humans (0:24:00) Evidence that Fasting can Attenuate Human Disease (0:25:11) Different Fasting Regimens Watch the full episode here - https://youtu.be/J736mfy7KEgFrom Modern Wisdom Podcast episode #066 PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years?-. This dietary recommendation serves as a purpose of weight loss technique. 987. He drinks little to no alcohol . He recommends senolytics for fewer old cells, intermittent fasting, cold and hot therapies, and supplements like NAD+, resveratrol, and polyphenols. Hello100 is a life science company researching the mechanisms of healthy aging and life extension. Shrimp is a very good source of protein while being low in calories. Similar to what the body does when it faces dieting. There are deeper benefits to shorter time frames for eating, such as 20/4). Once I get off the 10 days, which breaks the back of my sugar cravings, Ill continue the water and tea before 11:00 and do lower carb whole foods. The protein will stop your hunger. He also drinks a green drink (Athletic Greens) in the morning so as to provide some nutrition to hold him till dinner. He is currently the director of the Cardiovascular Fellowship Training Program at the Kettering Medical Center in Kettering Ohio. Here are a few highly nutritious foods that should be considered. The Prolon Fasting Mimicking Diet advocated by Dr. Valter Longo. We discuss the drugs David Sinclair takes here. "I'm big on intermittent fasting and restricting calories, and I think people should not snack-it's much better to have your three meals a day," says Dr. Sinclair, who also advocates skipping breakfast. In addition to sirtuins, another molecule important for longevity is mTOR (mammalian target of rapamycin), except this one is better if not activated. Basically this is the Holy Grail of exercise-the after burn. How does fasting promote longevity? Thank you for presenting an honest discussion of the FACTS. Those benefits also include the increase of, levels, and the ability to modify longevity regulators such as. Meditation is a practice of quieting the mind and deeply focusing for a certain period. For the 5:2 plan you could cut down to 1500 calories on your fasting days for several weeks then to 1000 calories, and then finally to the target goal of 500-600 depending on gender. Dr. Sinclair, the author of the book Lifespan: Why We Age & Why We Don't Have To, is a tenured Professor of . SU. He recommends trying different diets and fasting regimens and testing with a __ like Inside Tracker. As we all enter, I would really love [], Follow our journey @NovosLabs to be #YoungerForLonger. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. According to professor David Sinclair, PhD, . I know many have had success with the keto diet to lose weight, but there are some significant issues that you should be aware of, and honest about, as there is an easier way to become ketotic. They had a professional chef cook them a healthy 1800 calorie a day diet. Plus, if you decrease your calorie intake, tons of cellular procedures are initiated. One person had cut back his diet to 800 calories a day and was still gaining weight! Why eat less often? Please hit that red SUBSCRIBE button! This seafood has astaxanthin, an antioxidant that can help to protect from free radical damage and lower the risk of cardiovascular and neurodegenerative diseases. Sirtuin genes get triggered by low energy. Its one that acts on many aging mechanisms. David Sinclair often consumes. Find your sleep sweet spot. When you exercise you break down muscle and stress joints and ligaments. The Rekindle Diet: Eating for Optimal Health and Longevity, NOTE FROM NILS: SOMEONE HAS BEEN BORROWING MY IDENTITY TO ASK FOR PRODUCTS TO REVIEW, Menopause Can Be Delayed And Doing So May Add Years to Womens Lives, One in Ten of the People in This Village are Centenarians. As told by Dr. Sinclair, the takeaways of this podcast are to (1) eat less, (2) avoid sugar, (3) reduce meat intake, and (4) eat more of a plant-based diet, like the Mediterranean diet. So what is intermittent fasting and what are the benefits? Its hard to sell your program if you focus on whats similar to other plans. According to Australian biologist David Sinclair, fasting can help slow down aging and extend healthspan. They include. UTC+2 ( CEST) Postal Code. Boca de Hurgano. If you stuff the same amount of food in during a shorter time interval its very unlikely that you will get any of the benefits mentioned above! They also were not started on any type of new exercise program. The road to nowhere! We all say that we want to lose weight, but to be more specific we want to lose fat, and less frequently acknowledged we want to build muscle. The Harvard scientist explains that red meat is non-beneficial. Dr. David Sinclair is well known for his spectacular work as a professor of genetics at Harvard Medical School, his longevity diet, and his lifestyle choices. Stevia and other naturally occurring zero calorie sweeteners are fine. Metformin or Exercise Whats Best for Anti-Aging? Natural supplements can replace prescription drugs-theyre safer and more effective.. Consider eating only one to two meals per day, exercising at a low intensity, and reducing or eliminating alcohol and meat to improve longevity. Is It Too Early To Start Biohacking In Your 20s? Beets are also low in fat and calories, but high in water, this way improving the balance of energy intake. Now if you are used to having fuel before you exercise this will take some time to adapt especially since carbs are the best fuel for all types of exercise. Dr. Sinclair says that sugar is bad because it will reduce longevity, lead to type 2 diabetes, and possibly cause cardiovascular disease. ](https://novoslabs.com/press-release-new-study-results-on-novos-ingredients/), Studies Show NOVOS Protects Against DNA Damage, Senescence. Programming the epigenome for health requires some hunger. Encouraging children go constantly eat and snack is not setting them up for a lifetime of health and longevity. I am educating them on health and the benefits of Intermittent fasting. It increases cell survival, it enhances metabolic pathways (better glucose and cholesterol maintenance), increase mitochondrial function and energy production, and increases the production of brain derived neurotrophic factor (BDNF) which improves brain function. 5:2 dieting - Take 75% fewer calories for two days every week. One is the old saying that whatever doesnt kill you will make you stronger. Theres an evolutionary theory that the reason we like the heat is that it simulates our African origins, where everything was hot and tropical, says Dr. Sinclair. Fasting, Aging & Longevity - Summary of Dr. David Sinclair's Research. The science seems very clear that there are benefits to activating AMPK. At the ranch their job was to lose weight. According to the. That method is intermittent fasting. In a recent study they measured the metabolic rates of contestants from the TV show The Biggest Loser they found that as they lost weight their metabolic rate dropped tremendously. Its essential (in his opinion) to avoid eating carbs in the morning which raise your blood glucose and insulin, then leave you feeling like youre starving. Your email address will not be published. The big three areas of healthy living are diet, exercise, and sleep. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuinsprotein-modifying enzymes that respond to changing NAD+ . Yes there is and no its not the keto diet. That fasting or eating the right foods, like the Mediterranean diet not just to slows down the ticking of the clock, but probably reverses your age is a mind-blowing concept, says Dr. Sinclair. Telephone prefix. So, opposite to the common three meals a day, intermittent fasting allows you to eat once or twice per day. I spent many years running (with no proper training) 6ks, 12ks even one marathon. Time restricted feeding (such as trying to not eat till dinner) (At least 16 hours of fasting a day) (16/8). Youve got to get at least five servings of fruits and veggies every single day, says Dr. Sinclair, who believes that both fruits and vegetables reduce the risk of cancer and other diseases by eliminating free radicals from the body. The concept of intermittent and low level stress is important. How Harvard Researcher David Sinclair (and . The fasting-mimicking diet involves lowering mTOR activity by reducing the consumption of branched-chain amino acids. Also, in the 2013 Adventist Health study, it was calculated that vegetarians live longer than non-vegetarians. A mouse study showed that caloric restriction shortened the lifespan of more mice (based on genes) than it lengthened. Less, and more, are associated with increased cardiovascular events and death. Eating meat is not going to kill you, but try to push yourself toward eating more plant based.. My time of exercise is most likely to occur during the hours I eat. That gives me two hours before bedtime at 10:00. Choose a more difficult workout that makes it difficult to say more than a few words without pausing for breath (also known as a hypoxic response). The Science of Studying, How Is the Brain Structured? Ive recently turned 66. It works well with NMN by activating Sirtuin genes and DNA repair. We dont want the hangries mice get angry during a fast and attack each other. Save my name, email, and website in this browser for the next time I comment. Thank you so much Dr Hahn! document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Your email address will not be published. The most important thing about beating aging is to know that the fate of your health is in your hands, says Dr. Sinclair, who believes people can significantly slow down the clock with healthy lifestyle choices. Ponferrada (Spanish pronunciation: [poferaa]) is a city of Spain, located in the autonomous community of Castile and Len.Ponferrada, the second most populated municipality of the Province of Len, is also the capital city of El Bierzo, the only comarca recognized as an administrative entity by law in the region.. Experiment with different fasting programs and see what works for you. Meditation may even help to increase your longevity. You can probably extend the life of mice by doing wheel running, but its not for another ten years-its maybe 5 percent longer., Dr. Sinclair should know, he conducted many of the first studies showing the health benefits of caloric restriction in yeast and its effects on human cells growing in lab dishes; later, these experiments led to clinical trials in humans. We should not be eating sugar (glucose or fructose) theyll get fatty liver disease. He skips breakfast and lunch on most days and starts his day only with a cup of black coffee. Very high levels of protein switch off the sirtuin genes. For example, the 16:8 intermittent fasting window means that 8 hours are provided for eating and 16 hours are provided for fasting. What should we eat? We don't know which one's best, but I don't eat breakfast . I also still have much effort left in the good sleep area. Although blueberries might seem little, they have big health benefits. This diet saves money on food, which may help people who struggle with the cost of supplements. It includes various supplements such as. are well known because of their essential vitamins, minerals, and plant compounds. There is a big water weight loss at the start. My biggest regret is that gerontologists have been focusing so much money on a very, very few approaches to anti-aging research, says Dr. Sinclair, who urges people to explore lifestyle choices that have been proven effective in prolonging life. All carbs in spinach consist of fiber, meaning that it is a significantly healthy vegetable. Required fields are marked *. Do you know what makes for the best anti-aging supplement? One, currently popular dietary technique that integrates all 3 of these areas is intermittent fasting. Dr. Sinclair recommends that people avoid heating food in plastic containers because it can cause toxic chemicals to leak into the food and lead to cancer and other disorders. David Sinclair uses intermittent fasting in his daily practice. This is by far the most relevant discussion of this issue that I have ever come across. He suggests several different variations of IF (intermittent fasting), saying that its currently unclear which method is best, but all are beneficial: Sinclair also says that a vegetarian diet can activate hormesis. Every time you eat fruit, its like eating sugar because the fructose in the fruit turns into glucose very quickly, says Dr. Sinclair, who recommends eating green vegetables and blueberries every day to get the maximum levels of antioxidants in your diet. Not just one or two. It is important to add foods to your diet that increase NAD+, a compound that helps to extend longevity. Theres a genetic pathway that gets triggered by low energy, says Sinclair. One of the properties that beets have is helping to balance human energy intake. I think the best way to quit smoking is not to start, says Dr. Sinclair, who believes people should make an effort to stop smoking because cigarette smoke remains in the body for a long time after you finish your last cigarette and can cause cancer even if it has been years since you lit up. The famous and admired Harvard professor known as David Sinclair has been turning heads because of his great insight on longevity. In 2014, he was on Time Magazine's list of the "100 Most Influential People in the World," and . Choose higher-intensity exercise (HIIT workouts are recommended). You can read up on David Sinclairs Supplement Regime here. Ill be your host for today. Its called starvation. David Sinclair looks considerably younger for his age (he is currently 52 years old). Another problem is that energy/calories burned does NOT happen in a linear relationship with exercise time. I am so elated by the fact that it is so much easier and convenient to maintain for my busy lifestyle. Thanks much. However, it is important to stay cautious about taking Aspirin in large doses as it may lead to bleeding. Olympian yo-yo dieter with weight related diseases. Weve gotten rid of the idea that its just genes against destiny-we know that we can change the genes, and we can change our destiny., RELATED READING: Tim Ferriss Supplement Stack. Also when you exercise in a fasted state you pull more from fat, both in cardio or resistance exercise. Sinclair, David. It was difficult for him to fast all day till he learned that (for him) filling his body with fluids such as coffee or tea. If you are not achieving the stated goal of your plan then why would you continue to do it? The other method is resistance training. This article is an excerpt from the Shortform book guide to "Lifespan" by David Sinclair. I have recently tried to find out more about doing it the right way. She has a degree in Psychology and a deep passion for the subject. I limit calories greatly, but I do exercise every day, he says., RELATED READING: Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet, We all have a certain percentage of fat in our body, and we also have some sugar thats stored in the liver. Besides supplementing with groundbreaking anti-aging drugs such as NMNand resveratrol, David follows a strict diet and exercise routine. Its Cold and Flu Season. Fasting also has a protective effect against cancer and heart disease. If you want to eat meat, go for it. Read More Want to Protect Your Brain and Heart, Prevent Cancer, and Slow Aging? Theres no one size fits all when it comes to fasting. I thank you in advance for your time and help. It is because of brands like this that we . Eating Your Anthocyanins May HelpContinue, Read More Could Sirtuin 6 Activation Extend Lifespan in Humans?Continue, Read More Leucine Reverses Atherosclerosis and Lowers CholesterolContinue, Read More Myelin and the Aging Brain: Can Demyelination Be Reversed?Continue, Read More Metformin or Exercise Whats Best for Anti-Aging?Continue, Read More Its Cold and Flu Season. Their Diet May Be The Reason Why, Preventing Frailty: A Few Notes About Exercise, Nutrition, Black Cumin Seed Oil and Sea Buckthorn Berries. A Neuroanatomist Explains, Johann Hari: Why Antidepressants Dont Always Work, Geology Basics: A Practical Primer From Bill Bryson. For example, how should I get started? BPC 157 Has Profound Health Benefits. According to David Sinclair, it is one of the best things you can do for your health. In 3 months the subjects lost weight, lost fat, decreased their waist circumference, lowered their blood pressures, lowered their bad cholesterol levels (LDL), lowered their hemoglobin A1c levels (a measure of diabetic control), and slightly increased their sleep length. Now finally to exercise. Soluble fiber can help with cholesterol, as it binds to the bile and helps to remove it with the bodys waste. In other words, with high sugar, your defenses against disease and aging are minimal. Nils Osmar is an artist, writer, filmmaker, and teacher. Surrounded by mountains, the city straddles the course of the Sil River. Though Dr. David A. Sinclair has received numerous awards, he still works hard towards achieving more scientific breakthroughs and gives lectures to promote awareness about nutrition and dietetics. Now that I have lost weight and not regained my full appetite I want to consciously and mindfully practice your 3rd option Intermittent Fasting. Alcohol is a major carcinogen, says Dr. Sinclair, who believes that if you drink alcohol, you should limit yourself to one glass of wine per day. Dr. Sinclair believes that supplements might be a very important factor when preventing damage from free radicals and improving health. Sinclair has been skipping breakfast since he was a teenager (though he does take a couple of spoons of yogurt in the morning to make sure his supplements are absorbed). The trick, he says, is to fill yourself with fluids. Weight, rubber bands, or body weight exercises increase your metabolic rate for about 24-48 hours after you stop. That would be about 1 day week! I go today for CAT Scan for my stomach and pelvis as on 8/12/21 I had an endoscopy and colonoscopy. In fact, we need calories to avoid malnourishment and starvation. The first thing is that you cant outrun a bad diet. For example, you could eat for an 8-9 hour period and fast for the rest of the day or you might choose to eat only one meal a day for 2 days a week. According to the 2010 census ( INE ), the municipality has a population of 531 inhabitants. While exercising Dr. David Sinclair seeks to follow these aspects: Alongside a healthy diet, intermittent fasting, and exercise, there are a few more practices and products that the professor includes to increase his longevity and feel healthier. (They can also be activated by low heat; high heat; certain amino acids; high salt). They have a generous amount of antioxidants that create a barrier around the cell and reduce the impact of oxidative stress. You can get the benefits of exercise in three minutes a day just do sprinting to exhaustion, just push yourself as hard as you possibly can for about 3 minutes and then rest., Dr. Sinclair believes that when exercising, you should also breathe deeply and rapidly to boost oxygen in the bloodstream and increase caloric burn, which will help activate the Epigenetic clock. When I do this, I feel amazing and Im losing weight. Boca de Hurgano ( Spanish: [boka e weano]; Leonese: Boca de Grganu) is a municipality located in the province of Len, Castile and Len, Spain. David Sinclair takes 85 mg of Aspirin daily as it may protect against heart stroke. What Might Help?Continue, Your email address will not be published. So is there a way that we can more easily tap into fat without running for 2 hours a day? I really like his podcast. Like this article? Those benefits also include the increase of NAD+ levels, and the ability to modify longevity regulators such as SIRTs, NF-kB, AMPK, and mTOR in the right direction. in Persia and is one of the most nutritious leafy green vegetables. Supplements Intermittent cold exposure activates brown adipose tissue which burns calories to keep you warmer. Watch the full episode here - https://youtu.be/J736mfy7KEgFrom Modern Wisdom Podcast episode #066 PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years?-\r\rListen to all episodes online. It also shows an effect on the immune system and lowers cortisol levels (also known as the stress hormone). If you do not allow a time of recovery then there will be limited or no benefit. He notes that we dont fine giant men who are obese in nursing homes, but little women who are skinny, suggesting that being skinny promotes longevity. This has been called the constrained energy theory. Those constant (not intermittent) stressor lead to the breakdown of the human mind, body, and spirit. What is the easiest way to fast? You can lower your diet by: This practice provides specific feeding windows in which the follower can eat. We must fast to eat less often and regulate sirtuins, mTOR, and AMPK. This article has some show notes and a commentary on David Sinclairs new podcast (and a link to the video).. Sinclair has been skipping breakfast since he was a teenager (though he does take a couple of spoons of yogurt in the morning to make sure his supplements are absorbed). At his lab at Harvard Medical School, Dr. Sinclair and his team found that low energy activates sirtuins by causing our cells to make NAD+ (nicotinamide adenine dinucleotide), which sirtuins use as fuel. Sign up for a free trial here . . Like all diet fads, its new, trendy, and cool. The people in this study ate about 10% less food than they did before the study. The research comes (so far) from model organisms, not humans. You can read up on David Sinclairs Supplement Regime here. Mitochondria are organelles responsible for energy production, and their dysfunction is linked to aging. Its important to stay hydrated while fasting. His pattern is to fast, or refrain from eating (but not hydrating or drinking some liquids) for 12 to 16 hours per day. Youll probably be too tired to exercise as well. Natural supplements can replace prescription drugs they are safer and more effective. It helps you lose weight, but more importantly helps you lose fat while helping lower your blood pressure, blood glucose levels, and cholesterol levels. RELATED READING: Dr. David Sinclair's Anti-Aging Protocol Fasting Time Period The crux of Dr. Huberman's diet is the fasting time period. Enjoyed reading this article when I read that my body mass was that of 109 year old woman I have to do something I am 76 years old so I know I have not one foot on a banana peel but both so I would like to save a few months of life. Theres a lot of evidence that caloric restriction works and exercise works., RELATED READING: Dr. Andrew Hubermans Sleep Cocktail, Dr. David Sinclair believes that exercise should be high-intensity so it can trigger The Epigenetic clock. So we know what intermittent fasting is, but why would we want to do it? Calorie restriction has been shown to work in every animal except humans, says Dr. Sinclair, who believes that reducing daily caloric intake by 30 percent should result in increased longevity. These statements have not been evaluated by the Food and Drug Administration. But this is not a recipe for longevity. When were hungry, autophagy kicks in and recycles old protein fragments. Cut down on the sugar intake. We have all seen, or even experienced the destruction that goes along with chronic stress from a terrible job, family illness, money worries, etc. We compiled a whole list of things you can do to live longer here. As you can see 3 of the 4 factors are low level stressors. Thank you for the information. This seafood has astaxanthin, an antioxidant that can help to protect from free radical damage and lower the risk of cardiovascular and neurodegenerative diseases. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. Cognitive health can be improved by eating shrimp as well. However, it is not advised to practice calorie restriction for a long time because the body asks for BMI equilibrium. Telomeres are small complexes of DNA and proteins at the ends of our chromosomes that get shorter each time a cell divides. Can We Increase It Naturally in the Body? Some feel that the longer they stay up, the more calories they will burn, but what studies have found is that the longer you stay up the more calories you take in! Just skip breakfast instead. Dr. Sinclair is huge advocate for taking Nicotinamide Mononucleotide (NMN) and Resveratrol which made red wine famous for being known for extending your life in small amounts. This blog will share all the dietary recommendations by the longevity mentor. Dr. Hahn, Thank you for this information. In summary, intermittent fasting is simple, easy to do, adaptable to your lifestyle. We are all doing well. Myelin and the Aging Brain: Can Demyelination Be Reversed? Of course, looking younger for your age can be because you have good genes. However, mostly, it has to do with lifestyle. We dont know if he still takes these supplements, or whether he takes additional supplements, that are not included on this list. So far, I havent had any problems with IF. According to Australian biologist David Sinclair, fasting can help slow down aging and extend healthspan. Sinclair also says that fasting isnt easy, but its worth it. According to David Sinclair, "Almost any periodic fasting diet that does not result in malnutrition is likely to put your longevity genes to work in ways that will result in a longer, healthier life.". On his runs he drinks a high carb drink that is more concentrated than the typical sports drink. is a geneticist at Harvard Medical School and a Co-founder and Co-chief editor of the journal Aging. Through all that I figured I learned about every which way a body is not suppose to go and most of those lessons probably came the hard way. Dr. Sinclair urges people to avoid alcohol as much as possible because of its link to cancer. Sinclair says, you want the body to be in a state of perceived adversity. He explains that in a clinical trial, the fasting-mimicking diet was shown to help cancer patients survive and get over chemotherapy quicker. According to Harvard professor David Sinclair, his interest in cold therapies started in 2008. It is very informative. Telogen, 630 Third Ave. Suite 1502 NY 10017. David Sinclair's diet is a combination of 3 main principles of healthy living. Required fields are marked *. [Learn More. Most people on the diet never bother to check if they are ketotic. He religiously takes resveratrol, vitamin K2, NMN, metformin, and vitamin D3 on a regular basis.
david sinclair fasting